Download Applied Dermatotoxicology. Clinical Aspects by Howard Maibach, Golara Honari PDF

April 11, 2017 | Dermatology | By admin | 0 Comments

By Howard Maibach, Golara Honari

Applied Dermatotoxicology: medical Aspects presents concise, systematic, and state of the art details at the toxicological results of gear on pores and skin, and up to date advances in dermal toxicity trying out.

This e-book in particular addresses the medical displays borne out of publicity to various chemical substances. It starts with an summary of dermis biology to supply toxicologists with a easy figuring out of its anatomy and body structure. subsequent it offers a number of dermatotoxicological results, besides on the poisonous brokers that reason them, with colour images to demonstrate those results.

Applied Dermatotoxicology: medical Aspects is a vital reference for toxicologists in undefined, and for these doctors who come across circumstances of dermal publicity to poisonous brokers.

  • A concise, but inclusive evaluate of results of chemical exposure
  • Includes heritage on uncomplicated dermis biology
  • Provides very important medical reference for toxicologists in non-clinical settings

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Extra resources for Applied Dermatotoxicology. Clinical Aspects

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14. Muller L, Kasper P, Kersten B, Zhang J. Photochemical genotoxicity and photochemical carcinogenesis—two sides of a coin? Toxicol Lett. 1998;102À103:383À387. 15. Gocke E. Photochemical mutagenesis: examples and toxicological relevance. J Environ Pathol Toxicol Oncol. 2001;20(4):285À292. 16. Archier E, Devaux S, Castela E, et al. Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review. J Eur Acad Dermatol Venereol. 2012;26(suppl 3):22À31.

Highest concentration should be physiologic, not exceeding 1000 µg/ mL and osmolality should not exceed 10 mmolar. A geometric dilution series of eight test substance concentrations including a negative control or solvent are added to wells for 1 h (37 C, 5% CO2 in air). 52 • • • • • • Applied Dermatotoxicology A known phototoxic chemical (Chlorpromazine) is added to each well as a positive control. One set of wells is exposed to 5 J/cm2 in the UVA range for 50 min, while the other set is kept in dark.

Santos R, Goossens A. An update on airborne contact dermatitis: 2001À2006. Contact Dermatitis. 2007;57:353À360. 129. Swinnen I, Goossens A. An update on airborne contact dermatitis: 2007À2011. Contact Dermatitis. 2013;68:232À238. 130. Lachapelle JM. Occupational air-borne skin diseases. In: Kanerva L, Elsner P, Wahlberg JE, Meibach HI, eds. Handbook of Occupational Dermatology. Berlin: Springer-Verlag; 2000:122À134. 131. Fluhr JW, Akengin A, Bornkessel A, et al. Additive impairment of the barrier function by mechanical irritation, occlusion and sodium lauryl sulphate in vivo.

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