Download Advances and Technical Standards in Neurosurgery by K. Thapar, K. Kovacs, E. R. Laws (auth.), L. Symon, L. PDF

April 11, 2017 | Technical | By admin | 0 Comments

By K. Thapar, K. Kovacs, E. R. Laws (auth.), L. Symon, L. Calliauw, F. Cohadon, V. V. Dolenc, J. Lobo Antunes, H. Nornes, J. D. Pickard, H.-J. Reulen, A. J. Strong, N. de Tribolet (eds.)

As an addition to the ecu postgraduate education process for younger neurosurgeons we started to put up in 1974 this sequence of Advances and Technical criteria in Neurosurgery which was once later subsidized by way of the ecu organization of Neurosurgical Societies. This sequence used to be fust mentioned in 1972 at a mixed assembly of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the sequence being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbUhl. hence have been tested the rules of ecu co­ operation which were born from the ecu spirit, flourished within the ecu organization, and feature all through been linked to this sequence. the truth that the English language is easily to be able to turning into the foreign medium at eu medical meetings is a smart asset when it comes to mutual knowing. consequently we've got made up our minds to submit all contributions in English, whatever the local language of the authors. All contributions are submitted to the total editorial board earlier than publi­ cation of any quantity. Our sequence isn't meant to compete with the guides of unique medical papers in different neurosurgical journals. Our purpose is, quite, to offer fields of neurosurgery and comparable components within which vital contemporary advances were made. The contributions are written via experts within the given fields and represent the fust a part of each one volume.

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Death from pituitary carcinoma is invariably the result of mass effects from extensive intracranial disease. To date, relatively few patients have died as the direct consequence of extracranial metastatic disease (Pernicone and Scheithauer et al. 1993). In that neither the presence nor the treatment of systemic metastases appears to affect the prognosis of pituitary carcinomas, the frequency of metastases, particularly nonfunctioning ones, is probably under-reported. Thus the true incidence of pituitary carcinoma may be more ".

Therefore, pituitary tumors deemed monoclonal on the basis of allelic X-inactivation analysis may indeed have originated as polyclonal proliferations, but during the course of development, all clones except one were competitively eliminated. Should such a phenomenon be operative in the pituitary, hypothalamic dysfunction may prove to have a very genuine role in pituitary tumor initiation after all. A more persuasive role for hypothalamic dysfunction in pituitary tumorigenesis can be envisioned during the tumor promotion phase of the multistep model of pituitary tumor development.

1991). That corticotroph adenomas should, on rare occasion, be exceptions to the rule is not too surprising given that evidence -favoring a hypothalamic etiology for this tumor type has been notably stronger than for other pituitary adenomas. Thus, excluding isolated instances of corticotroph adenoma, pituitary adenomas can generally be regarded as monoclonal tumors derived from a single transformed cell, one in which nonlethal somatic mutation(s) have conferred a selective growth advantage. Whereas such a somatic mutation perspective conforms well to contemporary paradigms of human tumorigenesis, it also tends to minimize the role of hypothalamic influences in pituitary tumor development.

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